A fictionalized account of the life of William F. "Buffalo Bill" Cody. A hunter and Army Scout in the early part of his life, he rescues a US Senator and his beautiful daughter, Louisa Frederici. Cody is portrayed as someone who admires and respects the Indians and is a good friend of Yellow Hand who will eventually become Chief of the Cheyenne. Everyone else, including the military, politicians and businessmen on the other hand hate the Indians and are perfectly prepared to trample on their lands and destroy their buffalo hunting grounds. He's eventually forced to fight the Cheyenne however. He's also met a writer, Ned Buntline, who writes about Cody's exploits and he becomes a sensation when he travels East. His career is not assured however, particularly when he attacks those in positions of authority over their maltreatment of the Native American population. He eventually establishes his wild west show that becomes an international sensation.

Connie Ward is in seventh heaven when Gene Morrison's band rolls into town. She is swept off her feet by trumpeter Bill Abbot...

Hildy Johnson has divorced Walter Burns and visits his office to tell him that she is engaged to another man and that they are going to get married the day after. Walter Burns can't let that happen and frames the other man, Bruce Baldwin, for a lot of stuff getting him into trouble all the time, while he tries to steer Hildy back into her old job as his employee (editor of his newspaper).

Don Birnam, long-time alcoholic, has been "on the wagon" for ten days and seems to be over the worst; but his craving has just become more insidious. Evading a country weekend planned by his brother Wick and girlfriend Helen, he begins a four-day bender. In flashbacks we see past events, all gone wrong because of the bottle. But this bout looks like being his last...one way or the other.